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Lumière–Barbier method : ウィキペディア英語版
Lumière–Barbier method
The Lumière–Barbier method is a method of acetylating aromatic amines in aqueous solutions. An example of this is the acetylation of aniline.
First aniline is dissolved in water using one equivalent of hydrochloric acid:
Then 1.2 equivalents of acetic anhydride is added followed by 1.2 equivalents of aqueous sodium acetate solution. Aniline attacks acetic anhydride followed by deprotonation of the ammonium ion:
Acetate then acts as a leaving group:
The acetanilide product is insoluble in water and can therefore be filtered off as crystals.
==See also==

* Schotten–Baumann reaction

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